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The CHROMacademy Essential Guide Webcast:
What GC-MS Operators Need to Know


Thursday 15th January 2015,
8:00am PDT / 11:00am EDT / 16:00 BST / 17:00 CEST

GC-MS is a powerful technique used in many laboratories worldwide to gain both qualitative and quantitative information.  This webcast will improve your understanding of the theory and hardware used for GC-MS analysis whilst giving a clear insight into the variables which are key for successful analysis in a variety of application types.  We will discuss special GC considerations, how analyte ionization works and the principles of mass analysis using quadrupole devices.  We will show you how to interpret an MS tune report, the power of various MS operating modes and how to process and understand the data you generate.

Presented by Dr. John Langley (Southampton University) and Tony Taylor (Technical Director, Crawford Scientific).

  • Why do we use MS detectors with GC
  • Vacuum – don’t be scared!
  • What special GC considerations are there when working with MS detectors
  • Setting GC acquisition parameters
  • Electron Ionization (EI) and Chemical Ionization (CI)
  • Quadrupole mass analyzers Understanding ’tune’ reports
  • Setting MS acquisition parameters
  • Understanding GC-MS data

Key Learning Objectives:

  • Understand the hardware used, with special reference to the ionization source and mass analyzer
  • Appreciating the need for vacuum in MS analysis and how to work with vacuum systems
  • Understand how the ion source and quadrupole mass analyzers work
  • Understanding the variables which control the mass spectrometer and what a good GC-MS method protocol should contain
  • How to set-up and optimize the instrument for qualitative and quantitative analysis
  • Understanding and interpreting instrument Tune reports
  • Good practice in GC-MS data analysis
  • How to improve the sensitivity and robustness of GC-MS protocols

Who Should Attend:

  • Analytical scientists working with GC-MS who want to get the best performance from their equipment through a better understanding of the hardware and principles of the technique
  • Scientists who need to understand how GC-MS data are generated
  • Anyone who would to understand the possibilities of GC-MS analysis
 
What GC-MS Operators Need to Know
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eLearning Modules

 
Fundamental GC-MS - Introduction

An introduction to fundamental GC-MS concepts. The major components of the GC-MS instrument will be explained in detail; including coupling GC to MS systems, ionization processes, and mass analyzers.

Ionization - Electron Impact (EI) | Ionization - Chemical Ionization (CI) |
Mass Analyzers - Overview
| Mass Analyzers - Quadrupole

 
Fundamental GC-MS - GC Considerations

This module contains all you need to consider with regards to GC parameters when using GC-MS. The topics covered include carrier gases, injection and sampling modes, selection of column stationary phase and dimensions, and GC-MS fittings such as ferrules and septa. Each topic will give you the required knowledge and useful hints and tips to set up your GC analysis so that you get the best results which are compatible when coupling to an MS detector.

Carrier Gas | Columns | Stationary Phases | GC-MS Column Selection | Fittings

 
Fundamental GC-MS - GC-MS Interfaces

Ensuring the correct interface is used between the GC and MS instruments is paramount in GC-MS. This module will explain the working principles of GC-MS interfaces and how to select the correct interface for use with different types of GC columns and MS instruments. Common problems associated with the GC-MS interface are also discussed.

Coupling GC to MS Detectors - Jet Separator | Coupling GC to MS Detectors - Direct Interface | Column Diameter

 
Quick Guides
 
Fundamentals of GC-MS Ionization Techniques

Understanding how an instrument works is great, but when do you have time to read a text book, or go to a course? Let CHROMacademy help. Dip in and out of concise modules and take 5 minutes to learn a little about the fundamentals of your analytical technique. Why not delve into GC-MS ionization techniques right now?

Fundamentals of GC-MS Ionization Techniques

 
GC-MS Leak Detection

Leaks in GC-MS are particularly insidious. How do you know when you have a leak and where do you start to look for it.
It is something that will happen to all chromatographers at some point. Here is our quick guide to how to identify the source of GC-MS leaks.

GC-MS Leak Detection

 
 
The Secrets of Optimizing GC-MS Methods

The definitive guide to optimizing methods for GCMS analysis. In this session we consider the major instrument and method decisions that allow you to get the very best from your analysis.

The Secrets of Optimizing GC-MS Methods

 
Electron Ionization for GC-MS

This webcast will consider topics such as the anatomy of a typical EI source, the mechanisms of ionization, fragmentation and re-arrangement reactions and an introduction to EI mass spectral interpretation.
A must see for everyone using or developing methods for GC-MS.

Electron Ionization for GC-MS

 
GC-MS Ionization Processes

The two main forms of ionization, Electron Ionization (EI) and Chemical Ionization (CI), will be discussed in depth. The molecular reactions which occur within the ion source to produce ions will be examined along with which form of ionization should be used for particular analytes. Finally, our speakers will impart some of their expert knowledge regarding optimization of the GC-MS process and some general interpretation strategies.

GC-MS Ionization Processes

 
Understanding GC-MS Analysis

This webcast will present the fundamentals of using gas chromatography with mass spectrometric detectors. Key topics such as controlling and optimizing the vacuum system, ensuring good analyte transfer from the GC column, the theory and instrumentation of electron impact ionization and a detailed introduction to the quadrupole mass analyzer will be covered. A must see for everyone using or developing methods for GC-MS.

Understanding GC-MS Analysis

 
 
 
 
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  • Understand the hardware used, with special reference to the ionization source and mass analyzer
  • Appreciating the need for vacuum in MS analysis and how to work with vacuum systems
  • Understand how the ion source and quadrupole mass analyzers work
  • Understanding the variables which control the mass spectrometer and what a good GC-MS method protocol should contain
  • How to set-up and optimize the instrument for qualitative and quantitative analysis
  • Understanding and interpreting instrument Tune reports
  • Good practice in GC-MS data analysis
  • How to improve the sensitivity and robustness of GC-MS protocols

Who Should Attend:

  • Analytical scientists working with GC-MS who want to get the best performance from their equipment through a better understanding of the hardware and principles of the technique
  • Scientists who need to understand how GC-MS data are generated
  • Anyone who would to understand the possibilities of GC-MS analysis

Tony Taylor
Technical Director
Crawford Scientific

Dr. John Langley
Head of Mass Spectrometry
School of Chemistry, University of Southampton