No thanks! I would like to know more about CHROMacademy

 Over 3000 E-Learning topics / 5000 Articles & Applications
 

The CHROMacademy Essential Guide to
LCMS Method Parameters - Critical Evaluation

Thursday 28th February 2013, 11:00 AM EST, 16:00 GMT

  Parker Balston

In this session Arindam Roy (Associate Director, Quality, Novartis Consumer Health) and Scott Fletcher (Technical Manager, Crawford Scientific) will consider a range critical LC-MS method parameters and their impact on analytical sensitivity and specificity. The importance and impact of specific eluent chemistry, interface parameters, analyzer settings and types are all critically reviewed and evaluated in this highly relevant presentation

Critical Evaluation of LCMS method parameters – what does your method say about you!

  • Ever wondered why methods developed for LC-MS use TFA, TEA and other ion-pair reagents?
  • Ever wondered about the effects or organic modifier, buffer concentration or gradient analysis on LC-MS sensitivity?
  • Is there really a need to split column effluent flow on modern instruments?
  • Interested in how changing source voltages and parameters could effect ionization?
  • Ever questioned why specific scan times or ion dwell times are employed?
  • Interested in the benefits of using high accuracy and/or high resolution mass analyzers?
  • Are there any new column technologies that facilitate LC-MS analysis?

Who Should Attend:

  • Anyone working with LC-MS or LC-MS/MS who wants to get the very best performance from their equipment
  • Anyone wanting to improve their knowledge of the working principles of LC-MS analysis

Find out more about this Month's Essential Guide Webcast »

Content on this page requires a newer version of Adobe Flash Player.

Get Adobe Flash player

Sample CHROMacademy Content
Nebulisation - Spray Breakdown and Discharge


The Camtasia Studio video content presented here requires JavaScript to be enabled and the latest version of the Adobe Flash Player. If you are using a browser with JavaScript disabled please enable it now. Otherwise, please update your version of the free Adobe Flash Player by downloading here.

 

If you have any more questions on this or any other topic - please post them on our forum >>

loading data
loading data
loading data
loading data
loading data
Home | About UsContact Us | SubscribeTerms and Conditions | Advertise | Privacy Policy |

loading data

loading data

loading data

 

loading data


loading data

In this session Arindam Roy (Associate Director, Quality, Novartis Consumer Health) and Scott Fletcher (Technical Manager, Crawford Scientific) will consider a range critical LC-MS method parameters and their impact on analytical sensitivity and specificity. The importance and impact of specific eluent chemistry, interface parameters, analyzer settings and types are all critically reviewed and evaluated in this highly relevant presentation.

Arindam Roy Arindam Roy
Associate Director, Quality
Novartis Consumer Health
Scott Fletcher Scott Fletcher
Technical Manager
Crawford Scientific

Key Learning Objectives:

  • The impact mobile phase additives such as TFA, TEA and ion-pair reagents can have on analyte ionization
  • Effects of changing eluent modifier, buffer and ionic strength are considered in terms of the interface chemistry in API LC-MS
  • How flow rates effect ionization and whether there is still a need to split column effluent flow
  • The importance and criticality of common source parameters such as nebulizing and drying gas flows, capillary and declustering potentials, sprayer position etc.
  • The impact setting correct optimum scan cycle times and ion dwell times
  • When high resolution and / or high accuracy mass analyzers are required
  • How new LC-MS enabling column technologies permit enhanced ionization