What LCMS Operators Need to Know
Every LCMS operator should have certain knowledge and skills in order to produce the right quality data in the most efficient manner. This webcast highlights this knowledge and provides a very pragmatic guide to the day to day operation of an HPLC system with Mass Spectrometric detection as well as a valuable insight into the important variables from any LC-MS method.
Every MS detector needs to be set-up properly prior to analysis, which may include checks on important API interface parameters such as gas flows, nebulising voltages, source temperature and MS acquisition settings etc. A checklist of these items is good to follow and is often included in an instrument operation SOP – but do we always follow the SOP? When was the last time you questioned WHY, these variables are set at the values chosen? Have you ever used the phrase – ‘oh that value works for all of our methods’? If so then this webcast and accompanying tutorial is for you!
Once the method is set and equilibrated, test injections need to be made to assess the suitability of the system to produce valid analytical data. The baseline, chromatographic appearance and any quantitative output should be evaluated for suitability. What is the best way to do this?
Every LC-MS operator should be able to critically evaluate the method being implemented and understand the instrument settings as well as being able to notice parameter settings which are out of the ordinary. Problems may be anticipated and any allowable adjustments made to ensure that satisfactory data is produced.
Only by having the ability to properly implement an analysis and evaluate the quality of the data produced can an LCMS operator produce data which is fit for purpose on an on-going basis. Are YOU fit for purpose? This webcast will help to ensure that you are!
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