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Oxidation

Oxidation of methionine is another PTM often observed for protein biopharmaceuticals; it can be seen on the methionine residue of trastuzumab peptide T41 following trypsin digestion. In the example in Figure 1 increased levels of oxidation are present when the Herceptin sample is exposed to oxidative stress conditions (tert-butyl hydroperoxide, TBHP), with the oxidized peak eluting before the unmodified variant.

Oxidation of peptide T41

Figure 1: Oxidation of Herceptin peptide T41 under normal and oxidative stress conditions (tert-butyl hydroperoxide, TBHP).

 
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