| 1. | Improving Productivity and Compliance in the Bioanalytical Laboratory
This white paper demonstrates how the Waters Regulated Bioanalysis System Solution integrates into the
workflow of the bioanalytical laboratory... |
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| 2. | Rapid LC–MS-MS Analysis of Benzodiazepines and Barbiturates
Urinary testing for controlled substances is an important tool in preventing diversion and abuse of
these drugs. This application presents a... |
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| 3. | A New Solution to Sensitivity & Selectivity Challenges
Whether facing the challenges of resolving a chromatographic interference, eliminating high baseline
noise, or separating isomers, AB SCIEX... |
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| 4. | Analysis of PFCs in Environmental Water Using Triple Quadrupole LC–MS-MS
The detection of PFCs in rivers, food, and human blood has led to concern about their effects on
humans and the environment. This application... |
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| 5. | A Rapid and Sensitive Method Estimation of Octreotide in Human Plasma Using UPLC and Xevo TQ-S
A unique optimization of a Waters system for bioanalysis, from sample preparation to UPLC
chromatography to tandem quadrupole MS, enables the... |
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| 6. | Targeted Screening of Drugs of Abuse by LC-MS-MS
Screening of biological samples for drugs of abuse and their metabolites is the work of forensic
toxicology laboratories. This note shows a rapid... |
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| 7. | API Purification Using LC with UV and MS Detection
Purification of active pharmaceutical ingredients (APIs) often yields high numbers of fractions,
leading to a bottleneck of fractions to dry-down... |
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| 8. | Analysis of Methylglyoxal-Modified Heat Shock Protein 27 Using LC-MALDI
Methylglyoxal (MG) is known to form target proteins and stable adducts. Introduced here are the
results of analysis of MG modification of the... |
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| 9. | Quantification of Ethinyl Estradiol in Plasma at 1 pg/mL Using UPLC and Xevo TQ-S
In this study, an optimized combination of Waters technologies, including sample preparation
chemistry, UPLC chromatography, and the Xevo TQ-S... |
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| 10. | Analysis of Bisphenols in Canned Food by LC-MS/MS
A fast and sensitive method for the simultaneous analysis of BADGEs and BFDGEs in canned food and
beverages is described. |
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| 11. | Rapid Metabolite Identification using MetabolitePilotTM Software
This technical note describes how MetabolitePilotTM software and the AB SCIEX TripleTOFTM5600 System
can make the process of identifying and... |
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| 12. | Unravelling the Complexity of Fragrances in HPC* Products Using TruTOF GC–TOF-MS with
Automated Data Deconvolution
The composition and analysis of fragrance components in home and personal care (HPC) products is very
complex and unquestionably time consuming. |
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| 13. | Multiresidue Pesticide Analysis in Onion by a Modified QuEChERS Extraction and Ion Trap GC–MSn
Analysis
Most recently formulated pesticides are smaller in molecular weight and designed to break down rapidly
in the environment. |
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| 14. | LC–MS Analysis of Ionic Liquids, Counterions and Impurities Using the Trimode Acclaim Trinity
P1 Column
The term ionic liquid refers to organic salts with relatively low melting points (below 100
°C) that usually consist of an organic... |
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| 15. | Analysis of 17-Pesticide Residues in Apple Using Agilent SampliQ QuEChERS EN Kits and Agilent
J&W Ultra Inert columns by GC–MS
The QuEChERS method for pesticide analysis was first introduced by USDA scientists in 2003. The EN
method 15662:2007 is a European variation to... |
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| 16. | On-line SPE-LC of Catecholamines in Urine with Fluorescence Detection
Catecholamines are important markers for the diagnosis and management of tumour diseases of the
sympathoadrenal system. The major catecholamines... |
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| 17. | Tracking Flavours in White Wine and Coffee Flavour Profiling of Food Samples with SPME-GC–MS
and On-column Injection
SPME-GC–MS with on-column injection can be successfully employed for flavour profiling
of food samples. The on-column injector of the... |
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| 18. | Fast Analysis of Tobacco Nitrosamines in Cigarettes by LC–MS–MS
Tobacco specific nitrosamines (TSNA) are a group of carcinogens found only in tobacco products and are
formed from nicotine and related alkaloids... |
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| 19. | Simultaneous Extraction and Quantification of Morphine-related Compounds in Plasma Using Mixed-mode SPE and
UPLC–MS–MS
Zhe Yin, Kenneth J. Fountain, Erin E. Chambers and Diane M. Diehl, Waters Corporation, Milford,
Massachusetts, USA. |
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| 20. | ultrafleXtreme: Redefining MALDI-TOF-TOF Mass Spectrometry Performance
The new ultrafleXtreme exceeds any current expectations on MALDI-TOF-TOF technology: A proprietary kHz
smartbeam-II MALDI laser integrated with a... |
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| 21. | Flavour and Fragrance Analysis Easy Heart-cut MDGC with Mass Spectrometric Detection in 1st and 2nd
Dimension
This article reports on multidimensional gas chromatography using a multi-Deans switch that allows
easy heart-cutting. |
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| 22. | Hyphenated Techniques as Modern Detection Systems in Ion Chromatography
This article describes the use of combined ion chromatography-mass spectrometry (IC–MS)
and ion chromatography-inductively coupled plasma... |
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| 23. | Analysis of Pesticide Residues in Apples using Agilent SampliQ QuEChERS AOAC Kit by
LC–MS–MS Detection
Based on the QuEChERS AOAC Official Method 2007.01, 16 pesticides were used for evaluating the
performance of the Agilent's AOAC buffered... |
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| 24. | Simultaneous Extraction and Quantitative of Morphine-Related Compounds in Plasma Using Mixed-Mode SPE and
UPLC–MS–MS
Morphine is an effective pain-relieving drug that is primarily metabolized into morphine-3-glucuronide
(M3G) and morphine-6-glucuronide (M6G).... |
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| 25. | Rapid Screening of Pesticides Using U-HPLC/MS
The screening of pesticides, mycotoxins, and veterinary drugs is of great importance in regulated
environments such as food or feed analysis. Due... |
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| 26. | Analysis of Pesticide Residues in Apples Using Agilent SampliQ QuEChERS AOAC Kit by LC–MS-MS
Detection
Based on the QuEChERS AOAC Official Method 2007.01, sixteen pesticides were used for evaluating the
performance of the Agilent's AOAC Buffered... |
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| 27. | TSK-GEL Amide-80 HILIC Columns for the Analysis of Melamine and Cyanuric Acid in Milk by
LC–MS-MS
Melamine is an organic base and a trimer of cyanamide, with a 1,3,5-triazine skeleton. Melamine can
react with formaldehyde to produce melamine... |
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| 28. | Hyphenated Techniques as Modern Detection Systems in Ion Chromatography
This article describes the use of combined ion chromatography-mass spectrometry (IC–MS)
and ion chromatography-inductively coupled plasma... |
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| 29. | Robust and Fast Analysis of Four Tobacco Specific Nitrosamines in Tobacco Cigarettes by
LC–MS-MS Using RSLC PA2 Column
Tobacco Specific Nitrosamines (TSNA) are a group of carcinogens found only in tobacco products and are
formed from nicotine and related alkaloids... |
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| 30. | Rapid Field Detection of Chemical Warfare Agents, Simulants, By-Products, and Precursors Using Solid Phase
Microextraction and Portable GC-TMS
Rapid sample preparation using the CUSTODIONâ„¢ solid phase
microextraction (SPME) syringe was applied to chemical warfare... |
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| 31. | Identifying Drugs of Abuse Using Gas Chromatography-Time of Flight Mass Spectrometry (GC-TOFMS)
Illegal drug use worldwide is at an all time high. Forensic laboratories are seeing increased sample
loads creating an immediate need for fast... |
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| 32. | Lowering Detection Limits for the Analysis of PBDEs by Large Volume Injection and SIM on a Single
Quadrupole
Polybrominated diphenyl ethers (PBDEs) are bioaccumulativetoxic compounds that are used as flame
retardants. They have high boiling points and... |
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| 33. | Analysing Pesticides in Rice Using GC–MS–MS and QuEChERS Sample
Preparation
Confirmation and quantification of pesticide residues in rice can be accomplished with low detection
limits and high productivity by using gas... |
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| 34. | Comprehensive GC3GC(qMS) Qualitative and Quantitative Analysis of PCBs using EI and NCI Mode with a Rapid
Scanning Quadrupole Mass Spectrometer
Comprehensive GC×GC, invented by J. Phillips in 1989,1 has experienced
rapidly increasing interest in the last years. The original... |
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| 35. | Determination of Penicillins in Meat by High Performance Liquid Chromatography (HPLC-UV) and
HPLC–MS–MS
Penicillins are regulated substances in food for human consumption. The minimum residue limits range
from 1 ng/g to as high as 50 ng/g depending... |
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| 36. | Trace Level Analysis of Melamine in Milk Products on 7890A/5975C Using a New Agilent J&W DB-5ms
Ultra Inert Column and SamliQ SCX Cartridges
GC–MS method is presented for the quantitative determination and confirmation of
melamine residues in milk products. The milk sample was... |
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| 37. | Melamine and Cyanuric Acid Detection in 5 Minutes using LC–MS
Since September 2008, 294 000 infants and young children suffered urinary problems as a result of the
contamination of melamine in infant milk... |
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| 38. | Identification of Psychotropic Substances in Mushrooms by UHPLC–MS
Forensic laboratories face a daunting task to identify trace amounts of controlled substances in small
samples of seized evidence. Unambiguous... |
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| 39. | Analysis of Melamine and Related Analogs at 1 µg/g in Infant Formula by Gas
Chromatography/Mass Spectrometry
The recent establishment of a 1 μg/g safety threshold for melamine in
infant foods has led to an immediate need for more sensitive... |
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| 40. | Analysis of Polybrominated Diphenyl Ethers by Comprehensive GCxGC-TOFMS
Polybrominated diphenyl ethers (PBDE) are persistent environmental contaminants that are being
extensively studied by environmental researchers... |
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| 41. | Identification of Psychotropic Substances in Mushrooms by UHPLC/MS
Forensic laboratories face a daunting task to identify trace amounts of controlled substances in small
samples of seized evidence. Unambiguous... |
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| 42. | TSK-GEL Amide-80 HILIC Columns for the Analysis of Melamine and Cyanuric Acid in Milk by
LC–MS-MS
Melamine is an organic base and a trimer of cyanamide, with a 1,3,5-triazine skeleton. Melamine can
react with formaldehyde to produce melamine... |
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| 43. | Analyzing Pesticides in Rice Using GC–MS-MS and QuEChERS Sample Preparation
Thermo |
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| 44. | Using the Stratum PTC for Newly Proposed US EPA Method 524.3
Purge and trap concentration (P&T) along with gas chromatographic analysis is a widely
used method for the detection of volatile organic... |
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| 45. | Melamine and Cyanuric Acid Detection in 5 Min Using LC–MS
Since September 2008, 294,000 infants and young children suffered urinary problems due to the
contamination of melamine in infant milk powder and... |
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| 46. | LC–MS-MS Analysis of Malachite Green, Leucomalachite Green, Ciprofloxacin, and Tetracycline in
Food Samples Using an Online TurboFlow LC–MS Method
The analysis of chemical residues in food requires techniques sensitive enough to detect and quantify
contaminants at or below the maximum... |
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| 47. | Quantitation and Confirmation of the Pesticide Malathion in Fruit Samples using Multiple ReactionMonitoring
and MS-MS-MS
LC–MS-MS instruments operating in Multiple Reaction Monitoring (MRM) are widely used for
targeted quantitation on triple quadrupole and... |
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| 48. | GC–MS Screening for Melamine Adulteration in Baby Formula and Dairy Products
Melamine is an industrial chemical with a high nitrogen content that can cause kidney stones and lead
to renal failure. In some instances,... |
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| 49. | Extraction and Identification of Volatile Organic Compounds from Water in 70 s using SPME and a Hand
Portable GC-TMS
The CUSTODIONâ„¢ solid phase microextraction (SPME) syringe
was used to rapidly sample and concentrate volatile organic... |
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| 50. | Application of a GPC-LC–MS/MS Method for the Determination of 31 Mycotoxins in Edible
OIls
Gel Permeation Chromatography (GPC) is widely used for sample clean up in mycotoxin analysis. The most
commonly described methods use GPC columns... |
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| 51. | Determination of Trifluoroacetic Acid Using Ion Chromatography Mass Spectrometry
Perflourinated organic acids are ubiquitous and found at relatively low concentrations in the
environment (1). Trifluoroacetic acid (TFA) is the... |
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| 52. | A Highly Sensitive Method for the Analysis of Tamsulosin (Flomax) in Human Plasma
A highly sensitive analytical method for the analysis of tamsulosin in human plasma has been developed
for use in bioanalytical studies. The... |
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| 53. | Analysis of PCBs in Food and Biological Samples Using GC-Triple Quadrupole MS–MS
This application details a fast, reliable and highly selective trace-level screening method for the
quantification of polychlorinated biphenyls... |
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| 54. | maXis High Resolution LC–MS Makes the Most of Ultrafast LC Separations
An ultrafast gradient LC separation method was developed to separate a 5-component drug mixture in 30
seconds, with peak widths of 1 second.... |
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| 55. | Identification of Cannabinoids in Baked Goods by UHPLC–MS
Goal: Positively identify trace amounts of cannabinoids in a complex food matrix quickly, with minimal
sample preparation and no chemical... |
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| 56. | GC–MS Screening for Melamine Adulteration in Baby Formula and Dairy Products
Melamine is an industrial chemical with a high nitrogen content that can cause kidney stones and lead
to renal failure. In some instances,... |
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| 57. | The Benefits of Incorporating GC/QQQ into Pesticide Analysis Methods
Pesticide residue analysis is a complex task because the analyst often has to search for hundreds of
compounds in a wide variety of matrices. As... |
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| 58. | Analysis of Sulphonamide Antibiotics in River Water Using Equan, an LC–MS On-line
Concentration and Analysis System
Triple stage quadrupole LC–MS systems are often used for highly sensitive quantitative
analyses of environmental pollutants. The... |
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| 59. | Pesticide Analysis in Dietary Supplements Using Gas Chromatography Time-of-Flight Mass Spectrometry
Screening for pesticide content is a common analysis that is done in laboratories where many samples
need to be analyzed over a short period of... |
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| 60. | IC–MS Analysis of Low Molecular Mass Organic Acids in Beverages
Organic acids are present in many matrices and play crucial roles. Extensive research involving low
molecular mass organic acids (LMMOA) has been... |
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| 61. | Simultaneous Measurement of an API with its Counter-ion Using Corona CAD with HPLC-HILIC
The analysis of anions and cations is critical during drug development and related QC. Measure both
the API and the counterion in a single run. |
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| 62. | CAPCELL PAK C18 MG III, Polymer-coated C18 Stationary Phase, Designed for High-Sensitivity analyses in
LC–MS
The SHISEIDO CAPCELL PAK C18 MGIII is an HPLC column packed with a silicone polymer-coated phase,
providing excellent peak profiles for basic... |
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| 63. | Quick Start-Up for a Modified QuEChERS Multi-residue Pesticide Analysis in Lettuce by
GC–MSn
Use of a modified QuEChERS sample preparation procedure was fully evaluated for identification and
quantitation of pesticides in lettuce using... |
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| 64. | Study of Free Radical Fragment Ions Generated from ESI-CID-MS-MS Using LTQ and LTQ Orbitrap Mass
Spectrometers
Studies of odd-electron CID behaviors reveal that free radical fragmentation is structure-dependent
and is directly correlated with the... |
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| 65. | A Case Study of Using Thar SFC-MS Prep 30® to Purify Polar, Basic Pharmaceutical Relevant
Compounds
In the past decade, supercritical fluid chromatography (SFC) has experienced a striking resurgence and
exponential growth in acceptance,... |
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| 66. | Determination of Selected Pesticides and Flame Retardants in Drinking Water by SPE for UCMR2 and EPA Method
527 Using the Atlantic 527 Disk
The second unregulated contaminant monitoring regulation (UCMR2) program was developed to monitor US
drinking water sources for currently... |
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| 67. | Analysis of Melamine and Cyanuric Acid in Food Matrices by LC–MS-MS
In March 2007, several North American manufacturers of pet food voluntarily issued nationwide recall
notices for some of their products that were... |
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| 68. | CUSTODION ™ SPME Syringe for Rapid Sample Collection and Sample Preparation of Drinking Water
for the GC–MS Determination of Trihalomethanes
The CUSTODIONâ„¢ SPME Syringes are a series of novel solid
phase micro extraction syringes that incorporate Supelco... |
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| 69. | Increasing LC–MS–MS Sensitivity with Luna HILIC
The analysis of polar compounds in support of clinical and preclinical pharmacokinetic studies
requires an analytical methodology capable of... |
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| 70. | Analysis of Melamine and Cyanuric Acid in Food Matrices by LC–MS–MS
In March 2007, several North American manufacturers of pet food voluntarily issued nationwide recall
notices for some of their products that were... |
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| 71. | A Highly Selective Method for the Analysis of Drospirenone in Human Plasma
Several common birth control formulations contain both drospirenone and ethinyl estradiol. A highly
selective and sensitive analytical method for... |
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| 72. | A Small Molecule HPLC-Chip for the High-sensitivity Quantification of Pharmaceutcals using Triple Quadrupole
MS
The pressure to save active pharmaceutical ingredients drives the industry to scale-down laboratory
processes. This puts the burden on the... |
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| 73. | Evaluation of Extraction Methods and Bias Correction by EPA Method 6800 Protocol for Mercury Species in Tuna
Fish Tissue Using an Ion Chromatograph Coupled to an ICP–MS
Mercury pollution mainly originates from industrial activities such as chlorine production, rubbish
incineration and above all coal-fuelled power... |
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| 74. | Reducing Matrix Impact on Trace Analysis with GC–MS: A Simple Capillary Flow Technology
"Tee" for Improved Backflush Efficiency
Capillary flow technology (CFT) devices are microfluidic components that extend capillary GC
capabilities through simple and robust connections... |
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| 75. | Quantitative Analysis of Pseudoephedrine Tablets by UHPLC–MS
An effective UHPLC–MS method for high throughput separation, identification and
quantification of pseudoephedrine was developed on a... |
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| 76. | Quantitative LC–MS Analysis of Perfluorochemicals
This application note describes a fast and sensitive LC–MS method using a Hypersil GOLD
column on a Thermo Scientific LC–MS system... |
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| 77. | Fast Multi-Residue Pesticide Analysis Using Triple Quadrupole GC–MS–MS
H-SRM provides excellent selectivity for accurate identification and quantification of pesticides in
matrix, demonstrating high productivity for... |
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| 78. | New Generation of GC/High Resolution TOF-MS: APCI/APLI Source for Increased Flexibility
A new APCI/APLI source enables a high resolution TOF-MS to be coupled on LC and GC, thus increasing
flexibility and performance of TOF-MS in... |
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| 79. | Fast Multi-Residue Pesticide Analysis Using Triple Quadrupole GC–MS-MS
H-SRM provides excellent selectivity for accurate identification and quantification of pesticides in
matrix, demonstrating high productivity for... |
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| 80. | Analysis of Melamine and Cyanuric Acid in Food Matrices by LC–MS-MS
In March 2007, several North American manufacturers of pet food voluntarily issued nationwide recall
notices for some of their products that were... |
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| 81. | Analysis of Geosmin and 2-Methylisoborneol (MIB) by Solid Phase Micro Extraction (SPME) and CI-MS-MS using
the Varian 240 MS
Two of the most commonly occurring unpleasant odor-causing compounds in drinking water are geosmin and
2-methylisoborneol (MIB) (Figure 1).... |
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| 82. | Automated Extraction Technique for Improved Recovery of Phenols
Dionex has developed a new standard for flow-through solvent extraction which allows accelerated
solvent extraction (ASE®) of matrices... |
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| 83. | Analysis of Deoxynivalenol in Beer
Mycotoxins, toxic secondary metabolites of several fungal species, represent food safety issues of
high concern. Deoxynivalenol, the most... |
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| 84. | Metabolic Profiling of Peanut Plant Material by LC–TOFMS
There has been an increasing interest in the presence and availability of compounds in plant materials
that may possess bioactive properties, in... |
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| 85. | Quantitative LC–MS Analysis of Pefluorochemicals
This application note describes a fast and sensitive LC-MS method using a Hypersil
GOLDâ„¢ column on a Thermo Scientific LC-MS... |
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| 86. | Evaluation of Extraction Methods and Bias Correction by EPA Method 6800 Protocol for Mercury Species in Tuna
Fish Tissue Using an Ion Chromatograph Coupled to an ICP–MS
Mercury pollution mainly originates from industrial activities such as chlorine production, garbage
incineration and above all coal-fueled power... |
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| 87. | Increasing LC–MS-MS Sensitivity with Luna® HILIC
The analysis of polar compounds in support of clinical and preclinical pharmacokinetic studies
requires an analytical methodology capable of... |
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| 88. | The Use of Accurate Mass and MS-MS for the Analysis of PPCPs in Water
The United States Geological Survey (USGS) has found pharmaceuticals and personal-care products
(PPCPs) containing known or suspected... |
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| 89. | A Feasibility Study of Using Supercritical Fluid Chromatography (SFC)-UV-ELSD for Food and Beverage
Analyses
Supercritical fluid chromatography (SFC) is a normal phase separation technique. In SFC, supercritical
CO2 in combination with one or more polar... |
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| 90. | Quantitative Analysis of Pseudoephedrine Tablets by UHPLC-MS
An effective UHPLC-MS method for high throughput separation, identification and quantitation of
pseudoephedrine was developed on a Hypersil... |
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| 91. | Profiling and Characterization of Polyphenol Polymers from Cinnamon Using an Ion Trap Mass
Spectrometer
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| 92. | Determination of Geosmin and 2-MIB in Drinking Water by SPME-PTV-GC–MS
This application describes the analysis of two key taste and odour compounds in drinking water using
solid-phase microextraction and gas... |
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| 93. | Comprehensive 2D GC for Achieving Nitrogen Speciation in Middle Distillates
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| 94. | On-Line Sample Clean-Up for the LC–MS Analysis of Small Molecules in Serum
Drug discovery/detection commonly focuses on analytes which are present in biological matrices. Direct
injection of such samples onto LC and... |
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| 95. | Analysis of Wastewater for Volatile (Purgeable) Organics by GC–MS
A comprehensive approach to the analysis of volatile (purgeable) organics in waste and wastewater
allows straightforward achievement of method... |
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| 96. | Developing a Fast, Generic Method for Rapid Resolution LC with Quadrupole MS Detection
The Agilent 6140 quadrupole LC–MS, equipped with the multimode source and combined with
an Agilent 1200 Series Rapid Resolution LC system... |
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| 97. | GC–MS Determination of Phthalate Concentration in Plastic Toys
Phthalates are added to plastics to increase flexibility. Recently, concerns have been raised over the
effect of phthalate exposure from plastic... |
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| 98. | Comparing Manual Compound Optimizations Against Automated Optimizations Obtained by QuickQuan on the TSQ
Quantum Access
One of the rate limiting steps in LC–MS–MS sample analysis is the time
required to create accurate and sensitive instrument methods.... |
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| 99. | Profiling and Characterization of Polyphenol Polymers from Cinnamon Using an Ion Trap Mass
Spectrometer
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| 100. | GC-MS with a DART Ion Source
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