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The CHROMacademy Essential Guide Webcast:
Optimizing GC-MS and GC-MS/MS Analysis for Environmental Applications

Thursday 24th March 2016,
8:00am PDT/ 11:00am EDT/ 3:00pm GMT/ 4:00pm CET

Environmental samples present several analytical challenges such as, their sample matrix (large volumes of water, soil, air), complexity (large numbers of analytes of differing chemistries) and the requirement for increasingly reduced detection limits.  Analytical techniques, therefore, need to be able to meet these specific application needs and produce results in a timely fashion.  GC-MS and GC-MS/MS are highly applicable to environmental samples and can be used to combat the most challenging of analyses. 

This webcast will look at how to decide between GC-MS or GC-MS/MS analysis and once this decision has been made how to optimize the analysis in a variety of practical ways.  This will include approaches to increase throughput (fast GC columns) and maximize sensitivity (optimizing of ion source parameters, altering scan speed, or improving the speed and efficiency of collision processes in multiple reaction monitoring).

Presented by Dr Doug Carlton (Project Manager, Collaborative Laboratories for Environmental Analysis and Remediation, CLEAR) and Tony Taylor (Technical Director, Crawford Scientific).

Key Learning Objectives:

  • Methods of sample introduction
    • Large volume
    • PTV injection techniques
  • Fast GC columns for high throughput analysis
  • Optimization of ion source parameters for various environmental applications
  • Influence of scan speed on data collection in single quadrupole instruments - SCAN/SIM analysis and its applications
  • MS or MS/MS - what variables influence the decision?
  • Improving the speed and efficiency of collision processes in multiple reaction monitoring (MRM) GC-MS/MS experiments to optimize sensitivity • Databases for analyte identification and screening
  • Targeted versus non-targeted analysis in a range of environmental applications

Who Should Attend:

  • Anyone working with GC-MS or GC-MS/MS
  • Anyone working in the environmental testing sector

Presenter Information »


Optimizing GC-MS and GC-MS/MS Analysis for Environmental Applications - Tutorial

This month's webcast focused on using GC-MS and GC-MS/MS for analyzing environmental samples.  Now you can further your knowledge using the CHROMacademy material included in this month's tutorial.  The content provides information on ionization techniques, quadrupole mass analyzers, tandem MS/MS experiments, sample introduction techniques for large sample volumes and more. 

Our Quick guides, CHROMacademy course content, and archived webcasts and tutorials will provide you with the must know techniques for all GC-MS operators, practical tips on optimizing GC-MS methods, examples of applying  triple quadrupole MS/MS experiments to different application areas, and how to develop fast GC methods to increase throughput in your laboratory.

Watch the webcast

eLearning Modules

Fundamental GC-MS: Introduction

An introduction to fundamental GC-MS concepts. The major components of the GC-MS instrument will be explained in detail; including coupling GC to MS systems, ionization processes, and mass analyzers.

Why and when to use GC-MS | Ionization - Electron Impact | Mass Analyzers - Quadrupole
Tandem Mass Spectrometry

GC Sample Introduction

The definitive guide to a wide range of GC sample introduction techniques. This module utilizes CHROMacademy animations to show you how GC inlets work and how to optimize them in order to get the best out of your sample introduction. Some of the inlets covered include, split/splitless, cool-on-column, and programmed thermal vaporizing.

Programmed Temperature Vaporisation (PTV) Inlets | PTV Sample Flow Rate | PTV Liner Type and Packing
PTV Flow and Temperature | PTV Solvent Elimination

Quick Guides

Fundamentals of GC-MS Ionization Techniques

Understanding how an instrument works is great, but when do you have time to read a text book, or go to a course? Let CHROMacademy help. Dip in and out of concise modules and take 5 minutes to learn a little about the fundamentals of your analytical technique. Why not delve into GC-MS ionization techniques right now?

Fundamentals of GC-MS Ionization Techniques »


GC-MS Leak Detection

A practical guide to detecting, fixing, and preventing leaks in a GC-MS system.

GC-MS Leak Detection »


Does Mass Spectrometry Need Chromatography?

An interesting opinion piece by our MS Dean Kevin Schug on the merits of coupling chromatography with MS detection.

Does Mass Spectrometry Need Chromatography? »

What GC-MS Operators Need to Know

GC-MS is a powerful technique used in many laboratories worldwide to gain both qualitative and quantitative information. This webcast will improve your understanding of the theory and hardware used for GC-MS analysis whilst giving a clear insight into the variables which are key for successful analysis in a variety of application types. We will discuss special GC considerations, how analyte ionization works and the principles of mass analysis using quadrupole devices. We will show you how to interpret an MS tune report, the power of various MS operating modes and how to process and understand the data you generate.

What GC-MS Operators Need to Know »

GC-MS/MS Analysis - What You Need to Know

In this session, Dr Peter Tranchida and Josep Serret (Technical Training Consultant, Crawford Scientific) explore the theory, technology and applications of GC-MS/MS. They will discuss the key features of GC-MS/MS instrumentation alongside an overview of the key instrument operating principles and theories. Various means of deriving MS/MS spectral information will be discussed with reference to the analyzers which make these experiments possible and key applications of MS/MS technology will be highlighted to demonstrate practical relevance and show what GC-MS/MS technology can do for you!

GC-MS/MS Analysis - What You Need to Know »

GC-MS Ionization Processes

The focus of this Essential Guide webcast is GC-MS ionization processes. The two main forms of ionization, Electron Ionization (EI) and Chemical Ionization (CI), will be discussed in depth. The molecular reactions which occur within the ion source to produce ions will be examined along with which form of ionization should be used for particular analytes. Finally, our speakers Dr. John Langley (Southampton University) and Scott Fletcher (Crawford Scientific) will impart some of their expert knowledge regarding optimization of the GC-MS process and some general interpretation strategies.

GC-MS Ionization Processes »

The Secrets of Optimizing GC-MS Methods

The definitive guide to optimizing methods for GC-MS analysis. In this session we consider the major instrument and method decisions that allow you to get the very best from your analysis.

The Secrets of Optimizing GC-MS Methods »

Fundamentals of Triple Quadrupole in Applied Markets

Mass spectrometry is a powerful tool which can be used to overcome challenges which are faced in all sectors of analytical science, such as, clinical, food and beverage, environmental etc. These challenges include the requirement for lower detection limits, increasing sample and matrix complexity, and the need for high throughput. We will discuss the fundamental principles and major developments within triple quadrupole technology which allows these challenges to be met and overcome.

Fundamentals of Triple Quadrupole in Applied Markets »

Developing Fast Capillary GC Separations

The Essential Guide from LCGC’s CHROMacademy presents Developing Fast Capillary GC Separations. Dr. John Hinshaw (Senior Staff Engineer at Serveron Corp, CHROMacademy GC Dean) and Tony Taylor (Technical Director, Crawford Scientific), present a concise guide on increasing sample throughput for capillary GC for both existing standard equipment as well as the latest bespoke equipment and approaches for ‘Fast GC’.

Developing Fast Capillary GC Separations »

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Dr Doug Carlton (Project Manager, Collaborative Laboratories for Environmental Analysis and Remediation, CLEAR)

Doug comes from training as an analytical chemist specializing in method development for LC and GC with various spectroscopic and MS detector, predominantly applied to environmental applications. Doug currently devotes time to developing methods for unknown and targeted compounds in soil, water, and other matrices possibly contaminated through industrial processes. Doug is the Project Manager of the Collaborative Laboratories for Environmental Analysis and Remediation (CLEAR) and has spent the last 6 years developing, applying, and training with these methods as the field has grown.

Dr Doug Carlton

Tony Taylor Technical Director, Crawford Scientific

Tony comes from a pharmaceutical background and has many years' research and development experience in small molecule analysis and bio analysis using LC, GC and hyphenated MS techniques.
Tony is actively involved in method development within the analytical services laboratory at Crawford Scientific and continues to research in LC-MS and GC-MS methods for structural characterisation.
Tony is the Technical Director of the CHROMacademy and has spent the past 12 years as a trainer and developing on-line education materials in analytical chemistry techniques