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The term monoclonal antibody (mAb) is used to define a population of antibodies that are specific to a single antigen, which is what is required if mAbs are to be used as a biopharmaceutical therapy to target a specific disease or type of cancerous cell. This module provides an introduction to monoclonal antibodies.

 

Topics include:

  • Monoclonal antibodies
  • mAb post-translational modifications (PTMs)
  • Disulfide bond scrambling, isoforms, and aggregate formation
  • Glycoform variation in N-linked glycans
  • Deamidation
  • N-terminal pyroglutamic residues
  • C-terminal lysine truncation (clipping)
  • Methionine oxidation