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In its simplest form, the process of mass analysis in LC-MS involves the separation or filtration of analyte ion (or fragments of analyte ions), created in the atmospheric pressure ionization (API) interface or in the regions between the API interface and the high vacuum region of the mass analyzer. The analyte and fragment ions are plotted in terms of their mass-to-charge ratio (m/z) against the abundance of each mass to yield a mass spectrum of the analyte. There are several very popular types of mass analyzer associated with routine LC-MS analysis and all differ in the fundamental way in which they separate species on a mass-to-charge basis. This module will introduce the commonly used mass analyzers for LC-MS.


Topics include:

  • Introduction of quadrupole, time-of-flight and ion trap mass analyzers
  • Comparison of the different mass analyzers
  • Selection of the correct mass analyzer according to application requirements
  • Introduction to tandem mass spectrometry