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Troubleshooting LC-MS

This webcast will present a logical approach to identifying whether a problem has been caused by the sample/method or the instrumentation itself, followed by identifying which instrument component may be at the root of the issue. We will share tips and trick to help you identify the most common problems and how to properly set up your method and instrument.


Topics include:

  • Tools to diagnose the source of a problem
  • How to tune and what the tune report tells us
  • Troubleshooting common LC-MS issues
    • Contamination
    • Ion suppression or enhancement
    • Misidentification of the molecular ion
    • Poor signal reproducibility
  • Method/system parameters which should be considered
    • Buffer, flow rate, sample concentration
    • Use of divert valves, using scan function to visualize co-elution problems, source temperature