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LC-MS is a hyphenated technique, which combines the separating power of high performance liquid chromatography (HPLC), with the detection power of mass spectrometry (MS). LC-MS covers a broad range of application areas. This module explores the instrument acquisition methods used and examines the type of data that can be produced from such systems.


Topics include:

  • Definitions
  • Instrument fundamentals
  • LC-MS process
  • Why and when to use LC-MS
  • Ionization overview
  • Atmospheric pressure ionization (API)
  • Electrospray ionization (ESI)
  • Atomospheric pressure chemical ionization (APCI)
  • Atomospheric pressure photoionization (APPI)
  • Mass analyzers
  • Quadrupole mass analyzer
  • Time-of-flight mass analyzer
  • Ion trap mass analyzer
  • Tandem mass spectrometry (MS/MS)
  • Detectors