Working at a real LC-MS system and with real data, our technical team methodically take you through the practical process of LC-MS; from basic instrument setup, to mobile phase and signal optimization, and up to complex MS/MS experiments.

We demonstrate each stage while giving a clear explanation of the background science which underpins this practical approache, giving the user a detailed understanding of all the important aspects of LC-MS which are critical for reliable day-to-day running of this amazing technique.

During the training we will look at the following topics:

• Introduction
• Infusion
• Basic Signal
• Adducts
• Signal Optimization and Tuning
• CID
• MS/MS
• Isotopes
• SRM
• Conclusion

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Method development in the modern HPLC laboratory is challenging but can be approached very logically and is hugely rewarding when a fit for purpose method is produced. This course provides you with the underpinning knowledge to begin your HPLC method development career.

This course has been designed for those who are experience in HPLC and who are now looking to develop their experience and understanding of method development. During the course we will assume that you are familiar with the basic theories of liquid phase chromatographic separations, but we’ll also revisit some theory to underpin the teaching.

Course Delivery & Duration

• 4 video sessions - each session is between 1- 2 hours long
• Tutor supported with access to our chromatography experts
• Supporting training material
• Course assessment with certificate

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HPLC column dimensions will affect the efficiency sensitivity, and speed of an analysis. The choice of column dimensions will depend on the chromatographic application; analytical, semi-preparative, preparative, number of analytes in the mixture etc.  However, the dimensions can also be altered to improve chromatography by achieving more efficient, sensitive, and faster analyses.  The primary column dimensions of particle size, length, and internal diameter will be discussed and their effect on chromatographic separations demonstrated, providing some practical insight into how to select the best column dimensions for a particular application...

HPLC Column Dimensions »

Headspace sampling is excellent for the qualitative or quantitative analysis of volatile species in samples that can be efficiently partitioned into the headspace gas volume from either a liquid or solid matrix.  It is also a good technique for the analysis of samples where the entire sample should not be injected into the GC instrument (i.e. dirty samples).  Headspace sampling is also particularly amenable to the analysis of trace levels of analytes.  

Typical examples of headspace analyses include...

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