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This section explores the main GC considerations when using MS detectors. The choice of column phase and dimensions are considered, as well as the effects of carrier gas flows on the MS vacuum system.

At the end of this module you should be able to highlight the GC parameters which are of particular importance when using MS detection, make a suitable choice of capillary column bonded phase and column dimension for a particular separation type in GC-MS, demonstrate awareness of the impact of column bleed on MS hardware, choose appropriate GC carrier gas flow rates for the GC-MS experiment and be aware of the potential impact of high carrier flow on the GC-MS vacuum.


Topics include:

  • Carrier gas
  • Columns
  • Stationary phases
  • GC-MS column selection
  • Fittings
  • Guard columns (retention gaps)
  • Air leaks
  • Ferrules
  • Ferrules - practicalities
  • Septum overview
  • Septum selection
  • Septum considerations
  • Contamination