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In this session we consider the major instrument and method variables in LC-MS analysis as well as some of the more minor ones which can sometimes make a big difference to your analysis. Eluent chemistry, interface parameters, and analyzer settings are all considered in a lively discussion format where you will have the chance to ask questions
and get answers.


Topics include:

  • What HPLC eluent factors are important in optimizing response in LC-MS
  • What everyday factors in HPLC can be easily changed to increase sensitivity or improve separation in LC-MS
  • What API interface parameters really make a difference to LC-MS sensitivity or specificity
  • What MS parameters can be adjusted to improve analysis quality
  • What can your analyzer do for you!
  • Ion suppression and enhancement – an insurmountable problem?