Troubleshooting GCxGC Methods Is No Trouble

Comprehensive two-dimensional gas chromatography (GC×GC)-mass spectrometry (MS) is currently the most powerful tool for analyzing GC-amenable compounds, offering enhanced separation, sensitivity, and peak capacity. In this webcast, various aspects of GC×GC-MS are explored, including basic principles, method optimization, and troubleshooting, with a focus on cryogenic modulation. State-of-the-art instrumentation is discussed, highlighting advancements in modulator technology. Additionally, the advantages and limitations of GC×GC-MS compared to conventional GC techniques are examined. Practical strategies for maximizing performance are also reported.

Topics include:

• Fundamentals of comprehensive two-dimensional GC–MS (GC×GC–MS)
• Advantages over conventional GC: enhanced separation, sensitivity, and peak capacity
• Method development and optimization strategies
• Troubleshooting techniques specific to GC×GC–MS workflows
• Cryogenic modulation: principles and practical considerations
• Advances in GC×GC modulator and detector technologies
• Practical tips for maximizing system performance and data quality
• Limitations and considerations when adopting GC×GC–MS