Troubleshooting Karl Fischer

Thursday, May 21, 2025
8am PDT | 11am EDT | 4pm BST | 5pm CET

Karl Fischer titration is one of the most widely used techniques for accurate moisture determination, yet even experienced analysts encounter frustrating issues such as drift, poor repeatability, or disappearing endpoints.
If you routinely perform Karl Fischer moisture analysis in your laboratory, this focused one-hour webcast will help you identify, troubleshoot, and resolve the most common analytical problems that affect data quality.

Designed for analytical chemists, QC analysts, and laboratory scientists, this webcast provides practical guidance you can apply immediately to improve the accuracy, precision, and reliability of your Karl Fischer titrations.


Topics include:

  • Overview of the Karl Fischer reaction
  • Volumetric and coulometric methods
  • Drift
  • Sample handling and optimal weight
  • Sample solvent and capacity
  • Calibration
  • Common issues
    • Poor accuracy
    • Poor replicates
    • Disappearing endpoint
    • Over / under-titrating

 

Speaker

 

Colin Towers (Senior Technical Support Chemist, Crawford Scientific)


After completing a degree in pharmacy, Colin pursued a career in analytical chemistry. Following three years performing routine testing and three years instrument maintenance and calibration, he moved into a role as a method development and validation specialist in contract research. Gaining 11 years’ experience in developing methods for HPLC, LC-MS, GC, GC-MS and SPE in a high throughput commercial environment, this was supplemented by three years lecturing in forensic analytical toxicology and a further three years working as a community pharmacist. Colin has now been with Crawford Scientific since 2011 as a technical specialist, consultant, and trainer.

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