The Hidden Cost of Carryover in Protein A Chromatography

Tuesday, November 17, 2026
8am PST| 11am EST| 4pm GMT| 5pm CET

Carryover in Protein A chromatography can silently erode data quality, shorten column lifetime, and drive-up costs. Learn how optimized clean-in-place (CIP) strategies reduce carryover while preserving chromatographic performance, enabling longer column use, improved antibody titer accuracy, and more reliable results.

Explore representative titer and dynamic binding capacity (DBC) data from four diverse feedstocks of multi-specific and bispecific mAbs to see how these strategies translate into greater analytical performance. Discover how reduced carryover and improved column-to-column reproducibility support more consistent results across repeated injections, even without intermediate CIP.

Gain practical insights to minimize hidden inefficiencies, extend column lifetime, and increase confidence in analytical data, helping deliver more robust workflows, higher throughput, and better-informed decisions in Protein A analytical workflows.

 

Topics include:

  • The benefits of using a regular CIP strategy to extend column lifetime while maintaining chromatographic performance
  • How to minimize carryover to improve titer accuracy, sensitivity, and Protein A column robustness
  • How to improve Protein A column performance to increase sensitivity and streamline workflows across diverse cell cultures

Emery Domain (Evaluations Scientist, Waters Corporation)


Emery Domain is an Evaluations Scientist at Waters Corporation, where he has held multiple roles over nine years. He currently specializes in chromatography column development, supported by a background in antibody-based assay development, production and quality control. Emery works to empower Biopharmaceutical development labs with advanced chromatographic solutions, including the BioResolve Protein A Affinity Column.

William Smith (Menegatti Laboratory, NC State University)


William Smith is a fifth-year PhD candidate in the Department of Biomolecular and Chemical Engineering at North Carolina State University, where he is advised by Dr. Stefano Menegatti. His research focuses on developing affinity peptide ligands targeting AcMNPV baculovirus and Herpes simplex virus type 1. In addition to these core projects, he contributes to monoclonal antibody purification, Adenovirus purification, AAV purification, mRNA purification, and the development of 3D-printed chromatography support structures.

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