Advanced Analytical Solutions for Biotherapeutics: SEC Column Technology for AAVs, VLPs, and Ultralarge Biomolecules

The use of analytical size exclusion chromatography (SEC) for separation of oligonucleotides from other components based on hydrodynamic radius is complicated by the range of sizes that can be present as well as fundamental differences in the conformation between DNA and RNA. This makes selecting the correct pore size SEC column more challenging.

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