CHROMacademy Classroom

GC-MS Data Interpretation

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Instructor-led Training

This course explores the potential of GC analysis with mass spectral detection from a qualitative perspective. You will learn how to systematically analyse a mass spectrum to elucidate the underlying structural information.

Starting from first principles, the training introduces the fundamental chemistry of mass spectrometry and builds up to an examination of the most common fragmentation patterns.

This course is not instrument-specific and is suitable for anyone involved in mass spectrometry, from the analysts that wants to obtain good spectral data to the lab manager who needs to understand spectral interpretation in order to validate that data. 

This course is for users of GC-MS equipment, or anyone interested in structural elucidation by GC-MS.

CHROMacademy Classroom

Delivery Details

Duration: This course is delivered over two Live 4 hour sessions. Run on consecutive days.

Time: Each daily session runs from 9am – 1pm (Eastern Time Zone)

Number of delegates: Maximum of 10.

Price: $810 

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Course Overview

What You Will Learn: 

  • General concepts and benefits

  • Most critical parameters for HS sampling

  • GC requirements and specifics of HS instrumentation

  • Guidelines to method development

  • Quantitative approaches to HS analysis

Previous Experience: 

Good knowledge of chromatography and associated data.

Course content: 

Foundation 

  • Headspace principles

  • Boyle's Law

  • Dalton's Law of partial pressures

  • Matrix effects

  • Instrument Design

  • Vial pressurisation methods

Pressure Testing 

  • Sampling valve and carrier flow

  • Loop filling

  • Transfer line

  • Common problems and troubleshooting

  • Headspace Vials 

Vial types 

  • Closure types

  • Closure quality and pressure integrity

  • Vial size

Internal Standards 

  • Selecting an internal standard

  • Evaluating and optimising internal standard performance

GC Requirements 

  • Inlet types

  • Carrier requirements

  • Liner types

  • Oven conditions and focusing

Development and Optimisation of Conditions 

  • Solvent selection

  • Oven conditions

  • Fill volume

  • Use of salt

  • Sampling conditions

Total Headspace Extraction 

Multiple Headspace Extraction 

Standard Addition Method 

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