CHROMtalks - Deconvolution Demystified: Making Sense of Overlapping Spectra

Co-elution is a reality in GC-MS workflows - but overlapping spectra don’t have to derail your data. This session demystifies deconvolution: what it is, when to use it, and how to interpret results confidently. We’ll cover the underlying principles, show how algorithms like AMDIS work, and share practical tips to avoid false positives, improve quantitation, and increase method robustness.