CHROMtalks - Evaluating Hydrogen and Nitrogen as Alternatives to Helium for GC-MS Fragrance Analysis

Helium has long been the carrier gas of choice in GC-MS due to its inertness and excellent performance characteristics. However, increasing concerns over helium scarcity, rising costs, and environmental sustainability have spurred the need for alternative solutions. This presentation explores the viability of hydrogen and nitrogen as alternative carrier gases for the GC-(MS) analysis of fragrance samples using a comprehensive, real-world method development approach. The methodological challenges and practical considerations when transitioning from helium, including system safety, chromatographic and mass performance and impact on qualitative and quantitative determinations will be discussed. Key results from a recent study comparing separations, sensitivity, and efficiency across different carrier gases will be presented, offering critical insights for laboratories aiming to future-proof their workflows.