Understanding SIFT-MS

This module introduces the soft chemical ionization that underpins SIFT-MS analysis (and its specificity, in particular), the approaches to quantitation, and an overview of SIFT-MS method development and validation in the absence of chromatography. The module concludes with a summary sketch of how SIFT-MS complements the chromatographic methods.

Topics include:

• Specific analysis using ion-molecule reactions and MS
• Introduction to quantitation in SIFT-MS
• SIFT-MS method development: a brief primer
• SIFT-MS method validation: a brief primer
• SIFT-MS: complementing chromatography