Practical Considerations for MALS

Learn the practical steps needed to generate reliable, high-quality MALS data. Explore LC system preparation, tubing and detector configuration, mobile phase quality, baselines, concentration detection and sample preparation.

Discover how to assess system readiness, recognise common warning signs, understand when calibration standards are needed, and avoid common MALS myths and misconceptions. The module also covers post-run shutdown, storage and salt removal.

Topics include:

• What makes a MALS result reliable?
• Preparing the LC system before connecting MALS
• Tubing, dead volume, and detector configuration
• Mobile phase quality mattes
• Understanding baselines
• Choosing the right concentration detector for MALS
• Do I need calibration standards?
• Sample preparation for MALS
• First injections and system readiness
• Common warning signs
• After the run - shutdown, storage, and salt removal
• Common MALS myths and misconceptions