Impurity Profiling of GLP-1 Receptor Agonists by HILIC-MS

This app note introduces a HILIC-MS method using the Agilent 1290 Infinity III Bio LC and Altura Poroshell HILIC-Z column for impurity profiling of GLP-1 RAs.

Method eliminates nonspecific interactions with Ultra Inert column technology
Orthogonal separation approach resolving isomers
Method covers impurities of exenatide, semaglutide and tirzepatide

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