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mAbs - Introduction to Monoclonal Antibodies

The term monoclonal antibody (mAb) is used to define a population of antibodies that are specific to a single antigen, which is what is required if mAbs are to be used as a biopharmaceutical therapy to target a specific disease or type of cancerous cell. This module provides an introduction to monoclonal antibodies.

Topics include:

Introduciton to monoclonal antibodies
Monoclonal antibodies
mAb post-translational modifications (PTMs)
Disulfide bond scrambling, isoforms, and aggregate formation
Glycoform variation in N-linked glycans
Deamidation
N-terminal pyroglutamic residues
C-terminal lysine truncation (clipping)
Methionine oxidation

mAbs - Introduction to Monoclonal Antibodies

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