Scalable Purification of a Synthetic Oligonucleotide Using Agilent PL-SAX Columns
Offers a scalable purification method for siRNA using strong anion exchange chromatography and includes best practices for successful scale-up
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SAX chromatography enables sustainable and cost-effective purifications
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Analytical LC method scales easily to preparative LC with minimal changes
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The optimized method achieves 96% purity from the crude sample
