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CHROMacademy Classroom

GC Method Development

Live Online on 28th - 19th September

Instructor-led Training

This Gas Chromatography (GC) Method Development training course provides a step-by-step approach to developing effective, reliable, and optimized GC methods for analytical laboratories.

Supported by real-world separation examples, tutorials, and practical exercises, the course covers all the essential aspects of GC method development while helping participants build confidence in making informed chromatographic decisions. Designed for experienced chromatographers, the course provides a logical and structured approach that can help significantly reduce GC method development lead times.

Participants will gain a deeper understanding of the critical choices involved in gas chromatography method development, including column dimensions, stationary phase selection, inlet types and operating conditions, detector optimization, and sample preparation strategies. The course explains how each parameter influences chromatographic performance and demonstrates practical approaches to selecting the most appropriate conditions for GC analysis.

The course illustrates the effects of inlet conditions, oven temperature programming, stationary phase chemistry, and detector settings on the separation of real samples. Relevant chromatographic theory is applied throughout to support practical decision-making and method optimization.

This course takes a logical and progressive approach to GC method development, focusing on the important “make or break” decisions that determine method quality, robustness, and analytical performance.

This advanced GC training course is designed for experienced chromatographers and analytical scientists with a good understanding of gas chromatography who want to strengthen their GC method development skills and improve laboratory efficiency.

CHROMacademy Classroom

Delivery Details

Duration: This course is delivered over two Live 4 hour sessions. Run on consecutive days.
                      Each daily session runs from 9am – 1pm (Eastern Time Zone).

Price: $695 

Course Overview

What You Will Learn: 

  • Setting method development objectives
  • Sample preparation
  • Inlet and flow rate parameters
  • Choosing a column and temperature program
  • Optimization strategies

Previous Experience: 

Delegates should have a good knowledge of chromatography and experience as GC users. Some experience in method development is also recommended. A good grounding in chemistry will be beneficial.

Course content: 

Introduction

  • Establishing method objectives
  • Literature searching
  • What is known? / What needs to be known?
  • Introduction to Quality by Design (QbD)
  • Critical parameters and robustness

Sample Preparation

  • Sample clean up
  • Analyte extraction
  • Solvent selection
  • Optimizing for sample type/application

Inlet and Flow Rate Parameters

  • The effect of split ratio on peak shape and quantitative accuracy
  • Investigating oven initial temperature
  • Conversion into a splitless method
  • Optimizing purge-on time
  • Carrier gas choice and flow rate optimization (van Deemter & Golay treatment)

Choosing a Column and Temperature

  • Choosing the correct phase
  • Effects of column geometry
  • Solute-stationary phase interactions
  • Isothermal vs. gradient operation
  • Theory and development of temperature gradients

Optimization Strategies

  • Measuring and optimizing
  • Capacity factor, Efficiency, Resolution, Selectivity
  • Resolution equation
  • Developing effective methods
  • Example method development

Putting it all together!

  • Developing a method for the separation of a complex mixture of compounds from scratch